Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship
نویسندگان
چکیده
منابع مشابه
Mouse model of proximal tubule endocytic dysfunction.
BACKGROUND Several studies have indicated the central role of the megalin/cubilin multiligand endocytic receptor complex in protein reabsorption in the kidney proximal tubule. However, the poor viability of the existing megalin-deficient mice precludes further studies and comparison of homogeneous groups of mice. METHODS Megalin- and/or cubilin-deficient mice were generated using a conditiona...
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Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ultrafiltrate. This review focuses on the molecular bi...
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Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease worldwide, and is associated with increased morbidity and mortality in patients with both type 1 and type 2 diabetes. Increasing prevalence of diabetes has made the need for effective treatment of DN critical and thereby identifying new therapeutic targets to improve clinical management. Autophagy is a highly conserv...
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This in vitro microperfusion study examined the effects of growth hormone and insulin-like growth factor I (IGF-I) on proximal convoluted tubule (PC1) transport. Tubules were perfused with an ultrafiltrate-like solution and bathed in a serumlike albumin solution. Neither a physiologic (5 X 10-10 M), nor a pharmacologic (5 X 10jM) dose of growth hormone had an effect on PCT phosphate or bicarbon...
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The proximal tubule contains an autonomous renin-angiotensin system that regulates transport independently of circulating angiotensin II. Androgens are known to increase expression of angiotensinogen, but the effect of androgens on proximal tubule transport is unknown. In this in vivo microperfusion study, we examined the effect of androgens on proximal tubule transport. The volume reabsorptive...
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ژورنال
عنوان ژورنال: BIOCELL
سال: 2018
ISSN: 1667-5746
DOI: 10.32604/biocell.2018.07010